Guardians vs. Angels Prediction, Odds, Picks - April 6

Data Skrive

Ian Anderson will try to shut down Steven Kwan and company when the Los Angeles Angels play the Cleveland Guardians on Sunday at 4:07 p.m. ET, at Angel Stadium. The favored Guardians have -152 moneyline odds to win against the underdog Angels, who are listed at +127. Cleveland (-1.5) is favored on the run line. An 8.5-run total is listed in the game.

Here is everything you need from a betting perspective on the Guardians-Angels game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Angels Game Information & Odds

When: Sunday, April 6, 2025 at 4:07 p.m. ET
Where: Angel Stadium in Anaheim, California
How to watch on TV: FDSW and CLEG

Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Guardians -152 +127 8.5 -123 +102 -1.5 +114 -136

Guardians vs. Angels Prediction

Score Prediction: Guardians 5, Angels 4
Total Prediction: Over 8.5 runs
Win Probabilities: Guardians 56%, Angels 44%

Guardians vs. Angels Betting Insights

The Guardians won the only game they’ve played as the favorite this season.
Cleveland has not entered a game this season as bigger favorites on the moneyline than the -152 odds on them winning this game.
The implied probability of a win from the Guardians, based on the moneyline, is 60.3%.
The Angels have been victorious in two of the four contests they have been chosen as underdogs in this season.
Los Angeles has played as an underdog of +127 or more just one time this year and came away with a win in that game.
Sportsbooks have implied with the moneyline set for this matchup that the Angels have a 44.1% chance of pulling out a win.

Guardians Player Insights

Jose Ramirez leads the Guardians with four home runs and has put up a team-best batting average of .381.
Including all MLB hitters, Ramirez is 11th in batting average, 18th in on-base percentage, and second in slugging.
Ramirez carries a two-game hitting streak into this matchup. During his last five outings he is hitting .471 with two doubles, four home runs, two walks and five RBI.
Kyle Manzardo has capitalized on opportunities as he paces his team with eight RBI.
Manzardo is 35th in homers and 14th in RBI on the season.
Kwan is hitting .333 with a double, a home run and three walks.
Kwan has at least one base hit in three straight games. In his last five games he is batting .300 with two walks and an RBI.
Gabriel Arias has a double, a home run and two walks while hitting .333.
Arias has recorded at least one hit in five straight games. In his last five games he is hitting .375 with a home run, two walks and two RBI.

Angels Player Insights

Kyren Paris is batting .545 with a triple, a home run and two walks.
Paris’ home run total places him 74th in MLB, and he ranks 113th in RBI.
Paris carries a five-game hitting streak into this matchup. During his last five outings he is hitting .600 with a triple, a home run, two walks and three RBI.
Mike Trout has capitalized on opportunities as he paces his team with six RBI.
Among all MLB batters, Trout ranks 35th in home runs and 33rd in RBI.
Logan O’Hoppe has been solid source of run production for the Angels with three long balls and six runs batted in.
Nolan Schanuel leads the Angels with a .286 batting average.