The Arizona Diamondbacks (21-20) and the San Francisco Giants (24-17) open a 3-game set Monday. First pitch from Oracle Park is scheduled for 9:45 p.m. ET (FS1). Let’s analyze BetMGM Sportsbook’s MLB odds around the Diamondbacks vs. Giants odds and make our expert MLB picks and predictions for the best bets.
Season series: First meeting; Diamondbacks won 7-6 last year
The Diamondbacks split a 4-game home series vs. the LA Dodgers, wrapping up the set with an 8-1 loss as +107 underdogs Sunday with the Under (9.5) cashing. C José Herrera
drove in the lone run for Arizona Sunday, scoring CF Alek Thomas on a fifth-inning double to right field that cut the deficit to 5-1.
The Giants were swept in 3 games at the Minnesota Twins, including a 7-6 loss in 10 innings as +140 underdogs in the Sunday finale with the Over (8.5) hitting. San Francisco took a brief lead in the top of the 10th inning on a pinch-hit RBI groundout by 1B David Villar. However, RP Ryan Walker gave up 2 runs — 1 earned — in the bottom of the inning, including a walk-off single by Twins RF DaShawn Keirsey Jr. with 2 outs.
Diamondbacks at Giants projected starters
RHP Merrill Kelly vs. RHP Justin Verlander
Kelly (3-2, 4.09 ERA) makes his ninth start. He has a 1.05 WHIP, 2.5 BB/9 and 6.8 K/9 through 44 innings.
- Last start: Loss, 6 1/3 IP, 3 ER, 6 H, 0 BB, 6 K in 7-1 home defeat vs. New York Mets Wednesday
- 2025 road stats: 1-1, 5.31 ERA (20 1/3 IP, 12 ER), 18 H, 5 BB, 18 K in 4 starts
- 2024 vs. Giants: 1 road start (Sept. 5), no-decision, 7 IP, 2 ER, 6 H, 0 BB, 8 K in 3-2 setback
- Career vs. Giants: 7-5, 3.30 ERA (114 2/3 IP, 42 ER), 1.16 WHIP, 7.5 K/9 in 19 starts
Verlander (0-2, 4.50 ERA) makes his ninth start. He has a 1.31 WHIP, 3.2 BB/9 and 7.5 K/9 through 42 innings.
- Last start: No-decision, 5 IP, 3 ER, 5 H, 2 BB, 3 K in 14-5 victory in 11 innings at Chicago Cubs Tuesday
- 2025 home stats: 0-1, 4.87 ERA (20 1/3 IP, 11 ER), 19 H, 7 BB, 20 K in 4 starts
- 2024 vs. Diamondbacks: 1 home start (Sept. 8), loss, 3 IP, 8 ER, 8 H, 1 BB, 0 K in 12-6 defeat with Houston Astros
- Career vs. Diamondbacks: 5-2, 3.14 ERA (48 2/3 IP, 17 ER), 1.13 WHIP, 10.7 K/9 in 8 starts
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Diamondbacks at Giants odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:51 p.m. ET.
- Moneyline (ML): Diamondbacks -115 (bet $115 to win $100) | Giants -105 (bet $105 to win $100)
- Run line (RL)/Against the spread (ATS): Diamondbacks -1.5 (+145) | Giants +1.5 (-175)
- Over/Under (O/U): 8 (O: -105 | U: -115)
Diamondbacks at Giants picks and predictions
Prediction
Diamondbacks 6, Giants 5
Moneyline
ARIZONA (-115) is favored on the road despite San Francisco (-105) having a better record and riding a 3-game home winning streak. This line shows just how little confidence the market has in Verlander, who allowed 8 earned runs in 3 innings the last time he faced the Diamondbacks. The Giants are just 1-4 in Verlander’s last 5 starts and were swept in 3 games at Minnesota in their most recent series.
BET DIAMONDBACKS (-115).
Run line/Against the spread
Arizona -1.5 (+145) doesn’t pay out enough, and San Francisco +1.5 (-175) is too expensive.
PASS on the run line.
Over/Under
The Over has hit in 5 of Verlander’s last 7 starts. Giants games have also leaned heavily toward the Over this season when the market thinks San Francisco is outmatched, going 14-3 O/U when the Giants are underdogs, according to TeamRankings.com, which is tops in the majors.
BET OVER 8 (-105).
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